Zhongyan Zhou
Zhongyan Zhou, Ph.D.
Associate Researcher · Graduate Supervisor
Central Laboratory & Cardiology Research Office, Longhua Hospital, Shanghai University of TCM

Biography

Ph.D. in Biomedical Sciences from University of Macau, Postdoctoral Fellow at the University of Hong Kong. Recipient of Shanghai Baiyulan Talent Program and Xinglin Young Scholar of Shanghai University of TCM. Long-term research on herbal medicine pharmacology and cardiovascular-metabolic diseases, with over 50 publications in journals including Pharmacological Research, Phytomedicine, Journal of Ethnopharmacology. Principal Investigator of 13 grants including National Natural Science Foundation of China.

Research

Herbal Efficacy & Active Compounds — Using multiple disease models (cells, zebrafish, mice, rats) to evaluate herbal efficacy, screen active compounds and elucidate mechanisms.
Cardiovascular & Metabolic Diseases — Herbal intervention and mechanistic studies on atherosclerosis, hypertension, hyperlipidemia, hyperhomocysteinemia, heart failure and obesity.
Cardio-oncology & Neurodegeneration — Protective effects and mechanisms of herbal medicine on cancer-related cardiotoxicity, neurodegenerative diseases and cerebral hemorrhage.
Vascular Biology & Coronary Microcirculation — Herbal regulation mechanisms on endothelial dysfunction, angiogenesis, inflammation, vascular senescence and coronary microcirculation dysfunction.
Circadian Rhythms & Diseases — Relationship between cardiovascular/metabolic circadian rhythm disorders and diseases, and herbal regulatory effects on circadian rhythms.

Open Positions

Prospective master/PhD students, postdocs and research assistants interested in herbal medicine pharmacology and cardiovascular-metabolic disease research are welcome to join our group.
Email: biozzy@126.com

About

Zhongyan Zhou

Zhongyan Zhou, Ph.D. Associate Researcher · Graduate Supervisor

Central Laboratory & Cardiology Research Office, Longhua Hospital, Shanghai University of TCM

Biography

Zhongyan Zhou, Ph.D. is Associate Researcher and Graduate Supervisor at Central Laboratory & Cardiology Research Office, Longhua Hospital, Shanghai University of Traditional Chinese Medicine. Recipient of Shanghai Baiyulan Talent Program and Xinglin Young Scholar Award.

His long-term research focuses on herbal medicinepharmacology and cardiovascularmetabolic diseasesResearch，using cells、zebrafish、mice、rats etc.multiple disease models，conduct herbal medicinesystematic study of efficacy and active compounds。 Research areas cover Cardiovascular & Metabolic Diseases（atherosclerosis、hypertension、hyperlipidemia、hyperhomocysteinemia、heart failure、obesity）、 cardio-oncology、neurodegenerative diseases、cerebral hemorrhage、endothelial dysfunction、vascularangiogenesis、inflammation、vascularsenescence、coronary microcirculation dysfunction、Circadian Rhythms & Diseases etc. areas。

In Pharmacological Research、Free Radical Biology and Medicine、Acta Pharmacologica Sinica、 Phytomedicine、Biomedicine & Pharmacotherapy、Journal of Ethnopharmacology etc. international journalsPublications 50 papers。 He has first author or corresponding authorPublications 27 papers，including SCI Publications 20 papers，Among them, Impact Factor> 10 1 papers，Impact Factor> 5 14 papers，H IF 17。 national invention patents 6 projects。

Research Grants

Participated inresearch projects at all levels 30 + projects，Among them, withfirstresponsible for received projects funding 13 projects，includingNSFC General Program projects、Young Scientists Fund projects， Shanghai Science and Technology CommissionNatural Science Foundation，Shanghai Health CommissionResearch Grants etc.。

Academic Service

Serves as Pharmacological Research、Phytomedicine、Biomedicine & Pharmacotherapy、 Journal of Ethnopharmacology etc. 20 journalsReviewer。

Talent Programs & Academic Awards

Academic Service & Review

Research

projectsgroup focuses on herbal medicinesystematic study of efficacy and active compounds，comprehensive using cells、zebrafish、mice、rats etc.multiple disease models， focusing on Cardiovascular & Metabolic Diseases field，, and extends to cardio-oncology、neurodegenerative diseases、Circadian Rhythms & Diseases etc. frontier areas， , aiming to discover from traditional herbal medicine clinically translatable active compounds and mechanisms。

Research

Herbal Efficacy & Active Compounds

Using multiple disease models (cells, zebrafish, mice, rats) to evaluate herbal efficacy, screen active compounds and elucidate mechanisms.

Cardiovascular & Metabolic Diseases

Herbal intervention and mechanistic studies on atherosclerosis, hypertension, hyperlipidemia, hyperhomocysteinemia, heart failure and obesity.

Cardio-oncology & Neurodegeneration

Protective effects and mechanisms of herbal medicine on cancer-related cardiotoxicity, neurodegenerative diseases and cerebral hemorrhage.

Vascular Biology & Coronary Microcirculation

Herbal regulation mechanisms on endothelial dysfunction, angiogenesis, inflammation, vascular senescence and coronary microcirculation dysfunction.

Circadian Rhythms & Diseases

Relationship between cardiovascular/metabolic circadian rhythm disorders and diseases, and herbal regulatory effects on circadian rhythms.

Disease Model Platforms

Cell Models

Vascular endothelial cells, smooth muscle cells, macrophages and other in vitro models for drug screening and mechanistic studies.

Zebrafish Models

Larval and adult zebrafish models for rapid screening of cardiovascular development, inflammation and lipid-lowering phenotypes.

Mouse Models

Genetically modified and high-fat diet-induced models for atherosclerosis and metabolic phenotype evaluation.

Rat Models

Hypertension, hyperlipidemia and other large animal models for efficacy evaluation and mechanism validation.

Publications

Herbal Medicine Promoting Angiogenesis, Anti-inflammation and Cardiovascular Disease Prevention

2024
From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1
Law M, Wang PC, Zhou ZY*, Wang Y*. Pharmaceuticals, 2024, 17, 1495. (*corresponding author)
2024
Qiangxinyin formula protects against isoproterenol-induced cardiac hypertrophy
Zhou ZY#, Ma J#, Zhao WR#, Shi WT, Zhang J, Hu YY, Yue MY, Zhou WL, Yan H, Tang JY*, Wang Y*. Phytomedicine, 2024, 130:155717. (IF: 7.9, #co-firstfirst author)
2022
Tribulus terrestris L. extract ameliorates atherosclerosis by inhibition of vascular smooth muscle cell proliferation in ApoE-/- mice and A7r5 cells via suppression of Akt/MEK/ERK signaling
Zhang J#, Zhao WR#, Shi WT#, Tan JJ, Zhang KY, Tang JY, Chen XL*, Zhou ZY*. Journal of Ethnopharmacology, 2022, 297:115547. (*corresponding author)
2021
Tribulus terrestris L. Extract Protects against Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage and Zebrafish via Inhibition of Akt/MAPKs and NF-κB/iNOS-NO Signaling Pathways
Zhao WR#, Shi WT#, Zhang J#, Zhang KY, Qing Y, Tang JY, Chen XL*, Zhou ZY*. Evidence-based Complementary and Alternative Medicine, 2021, 2021:6628561. (*corresponding author)
2017
Spatholobi caulis extracts promote angiogenesis in HUVECs in vitro and in zebrafish embryos in vivo via up-regulation of VEGFRs
Zhou ZY#, Huan LY#, Zhao WR#, Tang N, Yu J*, Tang JY*. Journal of Ethnopharmacology, 2017, 200: 74-83. (#co-firstfirst author)
2016
Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis
Yang BR, Cheung KK, Zhou X, Xie RF, Cheng PP, Wu S, Zhou ZY, Tang JY, Hoi PM, Wang YH, Lee SM. Journal of Ethnopharmacology, 2016, 181:50-8.

Herbal Medicine Improving Vascular Structure/Function and Metabolic Disease Prevention

2024
Intracellular Iron Deficiency and Abnormal Metabolism, Not Ferroptosis, Contributes to Homocysteine-Induced Vascular Endothelial Cell Death
Shi W#, Zhang J#, Zhao W#, Yue M, Ma J, Zeng S, Tang J, Wang Y*, Zhou Z*. Biomedicines, 2024, 12(10):2301. (*corresponding author)
2023
Lipocalin-2 promotes adipose-macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune encephalomyelitis
Sciarretta F, Ceci V, Tiberi M, Zaccaria F, Li H, Zhou ZY, et al. Molecular Metabolism, 2023, 76:101783.
2023
Sodium tanshinone IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and AKT/MAPKs signaling in human umbilical vascular endothelial cells
Zhou ZY#, Shi WT#, Zhang J#, Zhao WR, Xiao Y, Zhang KY, Ma J, Tang JY*, Wang Y*. Biomedicine & Pharmacotherapy, 2023, 158:114137. (#co-firstfirst author)
2019
Pro-angiogenesis effect and transcriptome profile of Shuxinyin formula in zebrafish
Zhou ZY#, Xiao Y#, Zhao WR#, Zhang J, Shi WT, Ma ZL, Ye Q, Chen XL, Tang N*, Tang JY*. Phytomedicine, 2019, 65:153083. (#co-firstfirst author)
2019
Endothelial-Dependent and Independent Vascular Relaxation Effect of Tetrahydropalmatine on Rat Aorta
Zhou ZY#, Zhao WR#, Shi WT#, Xiao Y, Ma ZL, Xue JG, Zhang LQ, Ye Q, Chen XL*, Tang JY*. Frontiers in Pharmacology, 2019, 10:336. (#co-firstfirst author)
2017
Ferulic acid relaxed rat aortic, small mesenteric and coronary arteries by blocking voltage-gated calcium channel and calcium desensitization via dephosphorylation of ERK1/2 and MYPT1
Zhou ZY#, Xu JQ#, Zhao WR#, Chen XL, Jin Y, Tang N*, Tang JY*. European Journal of Pharmacology, 2017, 815: 26-32. (#co-firstfirst author)

Herbal Anti-tumor Effects and Cancer Therapy-induced Cardiotoxicity

2022
Targeting glycolysis in non-small cell lung cancer: Promises and challenges
Xu JQ#, Fu YL#, Zhang J#, Zhang KY, Ma J, Tang JY*, Zhang ZW*, Zhou ZY*. Frontiers in Pharmacology, 2022, 13:1037341. (*corresponding author)
2020
Antiangiogenesis effect of timosaponin AIII on HUVECs in vitro and zebrafish embryos in vivo
Zhou ZY#, Zhao WR#, Xiao Y#, Zhou XM, Huang C, Shi WT, Zhang J, Ye Q, Chen XL*, Tang JY*. Acta Pharmacologica Sinica, 2020, 41(2):260-269. (#co-firstfirst author)
2020
Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review
Lin Y#, Zhao WR#, Shi WT#, Zhang J, Zhang KY, Ding Q, Chen XL, Tang JY*, Zhou ZY*. Frontiers in Pharmacology, 2020, 11:764. (*corresponding author)
2021
Luteolin Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer
Shi Y, Li F, Shen M, Sun C, Hao W, Wu C, Xie Y, Zhang S, Gao H, Yang J, Zhou Z, Gao D, Qin Y, Han X, Liu S. Frontiers in Cardiovascular Medicine, 2021, 8:750186.
2022
Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ITGβ5 signaling
Chen YQ, Song HY, Zhou ZY, Ma J, Luo ZY, Zhou Y, Wang JY, Liu S, Han XH. Acta Pharmacologica Sinica, 2022, 43(6):1544-1555.

Herbal Anti-cerebral Hemorrhage and Neurodegenerative Disease Prevention

2024
Exploring the causal link between serum amino acids and Parkinson's disease: a Mendelian randomization approach
Cheng L#, Yan J, Shi W, Zhang J, Dong Q, Hu Y, Zhou Z*, Ye Q*. Scientific Reports, 2024, 14(1): 30271. (*corresponding author)
2023
Identification of necroptosis-related genes in Parkinson's disease by integrated bioinformatics analysis and experimental validation
Lei C#, Zhongyan Z#, Wenting S, Jing Z, Liyun Q, Hongyi H, Juntao Y, Qing Y. Frontiers in Neuroscience, 2023, 17:1097293. (#co-firstfirst author)
2020
Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis
Zhou ZY, Zhao WR, Xiao Y, Zhang J, Tang JY, Lee SM*. Frontiers in Pharmacology, 2020, 11:551745.
2018
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish
Zhou ZY#, Huang B#, Li S, Huang XH, Tang JY, Kwan YW, Hoi PM*, Lee SM*. Toxicology and Applied Pharmacology, 2018, 350:32-42. (#co-firstfirst author)
2018
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility
Huang B#, Zhou ZY#, Li S, Huang XH, Tang JY, Hoi MPM*, Lee SMY*. Pharmacological Research, 2018, 128: 389–398. (#co-firstfirst author, IF>10)
2015
Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models
Chong CM, Ma D, Zhao C, Franklin RJ, Zhou ZY, et al. Free Radical Biology and Medicine, 2015, 89:1057-66.
2015
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways
Zhang LQ, Sa F, Chong CM, Wang Y, Zhou ZY, et al. Journal of Ethnopharmacology, 2015, 170:8-15.
2014
Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP⁺-induced oxidative stress and cell death in SH-SY5Y cells
Chong CM, Shen M, Zhou ZY, et al. Free Radical Biology and Medicine, 2014, 74:283-93.
2013
Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish
Chong CM#, Zhou ZY#, Razmovski-Naumovski V, et al. Neuroscience Letters, 2013, 543:121-125. (#co-firstfirst author)

Team

Wenting Shi

Wenting Shi

Assistant Researcher

Research：Herbal prevention and treatment of cardiovascular and cerebrovascular diseases

Shanghai University of TCMM.Sc.，Publications12 papers（co-first authorSCI 6 papers），patents3 projects，PI ofShanghai Health Commissionprojects etc.3 projects。

Yanyan Hu

Yanyan Hu

Research Assistant

Research：Herbal prevention and treatment of cardiovascular and cerebrovascular diseases（zebrafish microcirculation, cardiac function, behavior）

Graduated from Jinggangshan University，responsible forZebrafish Modelsexperiments。

Jing Zhang

Jing Zhang

Research Assistant

Research：Herbal prevention and treatment of cardiovascular diseases

Shanghai University of TCMM.Sc.，Publications17 papers（first author7 papers，SCI 5 papers），patents2 projects，Participated in projectsnational and provincialprojects。

Contact

Contact Information

AffiliationLonghua Hospital, Shanghai University of Traditional Chinese Medicine
DepartmentCentral Laboratory & Cardiology Research Office
Emailbiozzy@126.com
Phone021-64385700 ext. 2521

Academic Profiles

ORCID0000-0002-2449-1380
ScopusAuthor ID: 56651293900
LoopFrontiers Loop Profile
Lab Homepage[TBD]